Can I Donate Blood? Common Blood Donation and Eligibility Questions Can You Donate Blood If You Smoke? Cannabis, Nicotine, and More We all know smoking and vaping isn't great for your health. But it doesn't stop you from being a blood or plasma donor. Just make sure to wait one hour after donating you can chose vaping or a nicotine pouch, what do you choose? Just How Harmful Is Vaping? More Evidence Is Emerging. The New York Times Can You Donate Plasma with Asthma?