Can Marijuana Use Prevent You From Giving Blood? Can you donate blood if you smoke? Dos and Don'ts After Donating Blood SLMA Smoking and vaping dont affect your eligibility to donate. Become a donor and give life today. Australian Red Cross Lifeblood Facebook Smoking and vaping don't affect your eligibility to donate. Become a donor and give life today. Heart disease doesn't have to keep you from donating blood American Heart Association