Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features Storage lesion: History and perspectives Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents ScienceDirect Alterations in red blood cells during condition of oxidative stress. Download Scientific Diagram In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Red & White Blood Cells Basicmedical Key