Simple cryosurgical treatment of the oral melanotic macule Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics a Melanotic macule at the wetdry line of the lower lip. b Melanotic Download Scientific Diagram Melanotic Macules, Naevi, and Melanoma Springer Nature Link Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Venous Lake of Lip and Lip Freckle Removal with Iridex Laser