The main mechanisms of MTX toxicity in experimental disease models of Download Scientific Diagram Mitochondrial glutathione redox cycle and interaction with other antioxidant MedLink Neurology Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It Busting the myth of methotrexate chronic hepatotoxicity Nature Reviews Rheumatology Methotrexate Support Bundle Theralogix Whey protein concentrate ameliorates the methotrexate induced liver and kidney damage British Journal of Nutrition Cambridge Core